mPEG-PCL Copolymer
●mPEG-PCL Product Description
The PCL segment has a relatively long degradation period, typically ranging from several months to more than one year, providing long-lasting mechanical support and controllable drug release behavior. By adjusting the block ratio and molecular weight of mPEG and PCL, the hydrophilic/hydrophobic balance, self-assembly behavior, and degradation rate of the copolymer can be precisely controlled to meet the requirements of different applications.
mPEG-PCL has good biocompatibility and excellent design flexibility. It has broad application prospects in long-acting drug delivery carriers, postoperative anti-adhesion barriers, tissue engineering scaffolds, and aesthetic medicine and medical applications such as dermal fillers.
The molecular weight distribution of the product is ≤2.0. Customized molecular weights and viscosities are available according to customer requirements.
Product Index:
| Item | Unit | Standard | Reference Standard | Method | Result |
| Appearance | / | White or off-white solid | / | Visual Inspection | White solid |
| Product Identification | / | Consistent with the standard map | / | ¹HNMR | Conforms |
| Intrinsic Viscosity [η] | dL/g | 0.3-0.4 | Pharmacopeia 0633 | 25℃, THF | 0.39 |
| Weight-Average Molecular Weight | / | / | / | GPC（CDCl₃） | 73563 |
| Molecular Weight Distribution | / | ≤2.5 | / | GPC（CDCl₃） | 1.60 |
| Molecular Weight of PEG | / | ~5000 | / | GPC（THF） | 6830 |
| Moisture | % | ≤0.5 | Pharmacopeia 0832 | Karl Fischer Coulometric Titration | 0.25 |
| Monomer Residue | % | ≤1 | YY/T 0661-2017 | GC | 0.75 |
| Solvent Residue (Total) | ppm | <1000 | Pharmacopeia 0861 | GC | 0 |
| Single Solvent Residue | ppm | ICH Q3C | Pharmacopeia 0861 | GC | Dichloromethane: 0 Anhydrous ethanol: 0 |
| Heavy Metal Residue (Pb) | μg/g | ≤10 (Pb) | Pharmacopeia 0821 | Pharmacopeia 0821 | Conforms |
| Sn Residue | μg/g | ≤150 | YY/T 0661-2017 | ICP-MS | Conforms |
Storage Conditions: Store in a low-temperature refrigerator at 2-8℃.
