PLGA

Short Description:

PLGA is a random copolymer, amorphous, widely used in surgical sutures, anti-adhesive films, tissue engineering scaffolds, absorbable microspheres, such as medicine-loaded slow-release microspheres, etc. Compared with PLLA, the polymer degradation time can be controlled by the GA content, and the material is soft and flexible.


Product Detail

PLGA is a random copolymer, amorphous, widely used in surgical sutures, anti-adhesive films, tissue engineering scaffolds, absorbable microspheres, such as medicine-loaded slow-release microspheres, etc. Compared with PLLA, the polymer degradation time can be controlled by the GA content, and the material is soft and flexible. Different types of PLGA can be prepared with different monomer ratios, e.g. PLGA 75:25 means that the polymer consists of 75%L-LA and 25% GA. The degradation time of PLGA is varied by the monomer ratio, the higher GA content, the easier it is to degrade.

Product Index(PLGA 50:50):

Item Unit Standard Values Reference Standard Method Result
Appearance / White to off white granules / Visual Inspection conforms
Intrinsic Viscosity [η] dL/g / YY/T 0661-2017

Refer to ASTM D 2857

 30℃ in Chloroform

0.40
Moisture % ≤0.3

GB/T 37642-2019

KFT 0.13

L-LA Monomer residue

% ≤2 YY/T 0661-2017 GC 0.17

GA Monomer residue

% ≤0.5 YY/T 0661-2017 GC 0.06
THF solvent residue ppm ≤720 YY/T 0661-2017 GC conforms
Total solvent residue ppm ≤1000 YY/T 0661-2017 GC conforms
Heavy metal residue(Pb) μg/g ≤10 YY/T 0661-2017 0841 Heavy metal detection method in Chinese Pharmacopoeia conforms
Sn Residue μg/g ≤150 YY/T 0661-2017 ICP conforms
Molar ratio  %  ±5 YY/T 0661-2017

HNMR(L-LA:GA)

48.4:51.6

 *Produced in GMP workshop, each batch will provide the corresponding COA report.

Model No. Intrinsic Viscosity [η] (dL/g) Test Conditions
PLGA8523 2.00-2.50 TCM,25℃
PLGA8531 2.70-3.50 TCM,25℃
PLGA7510 0.70-1.20 TCM,25℃
PLGA7520 1.80-2.40 TCM,25℃
PLGA7530 2.50-3.50 TCM,25℃
PLGA5003 0.20-0.40 TCM,25℃
PLGA5010 0.80-1.20 TCM,25℃
PLGA5014 1.20-1.60 TCM,25℃

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